Central nervous system, keep a heavy zoonoz (the disease from animals to people). Even today, people are lead to death. Factors, an RNA Rhabdoviruslar group virüsdür. Are found in the saliva of rabid animals and is usually spread by the bite. Of course, the vampire konakçı (blood sucking) bat that is found in fatty tissue and salivary glands. In all mammals except this bat does not take protective measures immediately, is always deadly. To date, symptoms occur only after you get rid of the three sides are available. Death, especially with respiratory paralysis happens.
The disease incubation period; eight days up to two years may vary. The average is forty days. Serum, or anti-rabies vaccine in this circuit is done without disease symptoms can be prevented. Purpose and high level of immunization in quickly in the body of virus neutralizing antibodies and is hasıl. Clinical symptoms after you quit, can not be expected to benefit from the vaccine. The main tool of the illness in people infected dog, the first symptoms; farkedilen if domestic animals are changing temperament. Animals do not do the usual movement, into the strange behavior. Grass, wood, fabric, etc. will try to eat something, cranky and irritable, the dream is different and the environment to attack, will run continuously, from the mouth of saliva flow and four-five days to develop a stroke-s dies.
Of disease development: The first event of the live virus into the skin or mucous membranes of the body is. Striated muscle cells in this area before the virus is replicated. The virus then enters nerve endings through, following the nerve path reaches the central nervous system. Virus in the blood may have as experience has shown. However, in the development of the disease that does not matter much. Virus replication in the brain immediately in only gray ore, through the autonomic nerves of salivary glands, kidneys later cloth, Bob Rek, lung, liver, skeletal muscles, skin and other organs such as heart can reach. The virus reaches the salivary glands infected with the disease will allow the saliva. Incubation period can be very different to the number of viruses into the body, where the distance to the central nervous system, the tissue and the amount taken depends on the person's defense mechanisms seem.
Placed in the central nervous system with the disease here, and increases the blood, nerve cells, and it starts to wreck beans peccant nerve cells, in the field from attack by the defense cells is eliminated. Regions with the increase of inflammatory cells in a brain inflammation occurs. Over time, the clinical progress grows well. Symptoms: bitten by rabid animals are treated is a human, the first symptoms, incubation 1 to 4 days after transfer may take. These symptoms, fever, headache, sensitivity, and itching over the bite, disappointment, fatigue, sore throat, muscle pain, easy fatigue, loss of appetite, nausea, vomiting and dry cough may be.
Emotional circuit; off into everything from the feeling of fear in the eyes, face mimik changed in the eyes of hâtıralarla are combative. Then unrest, belonging to the five senses and imagination, contentiousness, strange changes in thinking, to tighten the air flow, from the bright lights, loud sounds, the water is to develop ten or even fear to see. Sudan because of the fear is to swallow the muscle of the severe pain. The patient is unable to swallow the saliva foaming mouth, and finally died with a stroke.
Diagnosis: the patient to the clinical findings, then the story from the direction of a suspected rabid bite of hay van is to be found helpful in diagnosis. However, as important, patients without clinical findings is whether the determination is at risk. Because the clinical findings of treatment began after the success probability is very small.
Diagnostic laboratory findings on: Complications, unless the blood chemistry is normal. Blood circulating white sphere (leukocyte) count is increased slightly. However, from normal (5-7 bin/mm3) 30 bin/mm3 'may be in any value up. As with any virus infection following methods can be diagnosed precisely: from inflamed tissues and fluids (brain, saliva, cerebral-spinal fluid, etc.) and be shown the virus to be isolated.
A series of studies in people with serum Asis against rabies virus has increased four times the amount of antibodies that show. 3-virus in infected tissues is a sensitive method with the Fluorescent Antibody Technique of virus antigen to be displayed. Dead or dying brain tissue or the brain of the suspect animal studies can be done following biopsilerinden. Brain tissue in mice injected with the virus nümunelerinin to produce and isolate the work. Fluorescent Antibody Technique of the virus antigen to be displayed.
c) with light or electron microscopy of Negri cisimcik search. Negri and cisimcik; seller and pink-colored paint near the cell core of the rabies disease has virus particles. Ammon horn, especially in the brain, the brain shell, brain stem and cerebellum in the distribution indicates purkinje cells. Negri cisimcik view, the diagnosis of rabies is dealt, the view that meaning is not to be mad disease. Because 20% of rabies cases is shown.
Protection: Protection Principles; infected most important role to play is to eliminate the per-free dogs. Pets, rabies virus, compared with a high risk of the veterinary, cave developers, laboratory workers, animal care must be pre-vaccinated. Place immediately at the first opportunity for bite wounds suspect plenty of soap and water, must be washed. Treatment of conditions: Each year millions of people worldwide suspected of animals exposed to attacks, rather than all these people under treatment, the treatment is called the existence of certain conditions. Because the risks of vaccines and anti-serum treatment is available.
Animals attacking people without any reason if possible to catch. Captured wild or domesticated animals killed Asis head as soon as possible can be mad in the brain tissue that can be done in a laboratory examinations should be sent. This way the most reliable method, Tekniği'dir Fluorescent Antibody. If this technique can not be identified with rabies virus, rabies virus in the saliva of animals is not acceptable and does not require the treatment of people exposed to attack. Fluorescent Antibody Technique, however, remove, or if treatment müsbet icabeder of cisimcik Negri. The menu even if the examinations cisimcik Negri, kalclumaz out suspected rabies.
1) wound treatment: The animal suspected of rabies by the bite right at the first opportunity the place of soap and water or alcohol, such as tincture of iodine should be washed with disinfectant. Because rabies virus is sensitive to soap and alcohol. Of chemical disinfectants can be found as Zefıran or Cetavlon is also useful. Also implemented and tetanus vaccine for tetanus antibiotics (usually penicillin) should begin to be used.
2) Passive immunization: antiserumları is done with Jerusalem.
3 - Active immunization: Dead rabies virus vaccines are made with.
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